KMID : 0191120140290091217
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Journal of Korean Medical Science 2014 Volume.29 No. 9 p.1217 ~ p.1225
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Benefits of a Continuous Ambulatory Peritoneal Dialysis (CAPD) Technique with One Icodextrin-Containing and Two Biocompatible Glucose-Containing Dialysates for Preservation of Residual Renal Function and Biocompatibility in Incident CAPD Patients
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Yoon Hye-Eun
Chang Yoon-Kyung Shin Seok-Joon Choi Bum-Soon Kim Byung-Soo Park Cheol-Whee Song Ho-Cheol Yoon Sun-Ae Jin Dong-Chan Kim Yong-Soo
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Abstract
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In a prospective randomized controlled study, the efficacy and safety of a continuous ambulatory peritoneal dialysis (CAPD) technique has been evaluated using one icodextrin-containing and two glucose-containing dialysates a day. Eighty incident CAPD patients were randomized to two groups; GLU group continuously using four glucose-containing dialysates (n=39) and ICO group using one icodextrin-containing and two glucose-containing dialysates (n=41). Variables related to residual renal function (RRF), metabolic and fluid control, dialysis adequacy, and dialysate effluent cancer antigen 125 (CA125) and interleukin 6 (IL-6) levels were measured. The GLU group showed a significant decrease in mean renal urea and creatinine clearance (-¥Ä1.2¡¾2.9 mL/min/1.73 m2,P=0.027) and urine volume (-¥Ä363.6¡¾543.0 mL/day, P=0.001) during 12 months, but the ICO group did not (-¥Ä0.5¡¾2.7 mL/min/1.73 m2,P=0.266; -¥Ä108.6¡¾543.3 mL/day, P=0.246). Peritoneal glucose absorption and dialysate calorie load were significantly lower in the ICO group than the GLU group. The dialysate CA125 and IL-6 levels were significantly higher in the ICO group than the GLU group. Dialysis adequacy, ¥â2-microglobulin clearance and blood pressure did not differ between the two groups. The CAPD technique using one icodextrin-containing and two glucose-containing dialysates tends to better preserve RRF and is more biocompatible, with similar dialysis adequacy compared to that using four glucose-containing dialysates in incident CAPD patients. [Clincal Trial Registry, ISRCTN23727549]
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KEYWORD
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Biocompatibility, Peritoneal Dialysis, Continuous Ambulatory, Icodextrin, Randomized Controlled Trial, Residual Renal Function
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